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M94A3147.TXT
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1994-10-25
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Document 3147
DOCN M94A3147
TI Host immune response in chlamydial cervicitis.
DT 9412
AU Mittal A; Kapur S; Institute of Pathology, New Delhi, India.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):142 (abstract no. PA0189). Unique
Identifier : AIDSLINE ICA10/94369428
AB OBJECTIVE: To study host immune responses in chlamydial cervicitis.
METHODS: Cellular immune responses were studied in peripheral blood and
compared with local immune responses to chlamydial elementary bodies in
patients. RESULTS: No significant difference was noted in lymphoblast
transformation to antigens (PPD and C. trachomatis) between the control
group and patients with chlamydial cervicitis. Percent inhibition of
IL-2 production in cervical secretions ranged from 59% to 84% while
supernatants stimulated with PPD in these patients failed to show
inhibition. There was no inhibition of IL-2 production in
secretions/supernatants in C. trachomatis negative cases. Antichlamydial
antibodies (IgG or IgM) was present in all and IgA in 3 C. trachomatis
positive cases. DISCUSSION AND CONCLUSION: Local cell mediated immunity
is impaired in patients of chlamydial cervicitis, however, antigen
reactive T cells are present.
DE Antibodies, Bacterial/BIOSYNTHESIS/*BLOOD Antibody Formation
Cervicitis/*IMMUNOLOGY/MICROBIOLOGY *Chlamydia trachomatis Chlamydia
Infections/*IMMUNOLOGY Female Human IgG/BIOSYNTHESIS
IgM/BIOSYNTHESIS/BLOOD Immunity, Cellular Interleukin-2/BIOSYNTHESIS
T-Lymphocytes/*IMMUNOLOGY MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).